Psilocybin session and depression

Psilocybin session and depression (bron: Triptherapie)

The weather and depression The seasons can influence our mood and associated hormones and neurotransmitters cause, for example, the winter blues. For example, in winter […]

The weather and depression

The seasons can influence our mood and associated hormones and neurotransmitters cause, for example, the winter blues. For example, in winter many people experience a dip in their mood, which is also known as winter depression or seasonal depression. This can be caused by a lack of sunlight, which reduces the body’s own “happiness hormone” serotonin. In spring and summer, many people experience an improvement in their mood. This can be attributed to an increase in sunlight, which stimulates the production of vitamin D and the increase in serotonin due to exposure to daylight. The change of seasons can also affect the production of other hormones and neurotransmitters, such as dopamine, norepinephrine and cortisol, which influence our mood and physical well-being.

A lack of sun in winter

In winter when the days are shorter and there is less sunlight, our body can produce less vitamin D. This is because our skin naturally produces vitamin D when exposed to sunlight. Vitamin D is essential for a healthy immune system because it helps regulate our immune response. A vitamin D deficiency can therefore contribute to a weakened immune system and make us more susceptible to viruses such as colds, corona and flu. It is believed that normal vitamin D levels in the body can contribute to a more effective immune response to viruses. It is therefore important to get enough vitamin D, especially in the winter months when the sun shines less brightly. Supplementing vitamin D through diet or supplementation can help strengthen immunity and reduce susceptibility to viruses.

Preventing winter depression

There is increasing evidence that shows that there is a link between a well-functioning immune system, low inflammation levels and a lower risk of depression. Low-grade inflammation can occur when the immune system becomes overactive and attacks the cells and tissues in the body that it should normally protect. These inflammatory reactions are accompanied by an increased production of cytokines, substances that cause inflammatory reactions. Research shows that this inflammation can lead to changes in the brain that can contribute to the development of depression.

A well-functioning immune system and low inflammation levels can therefore protect against the development of depression. It is important, especially in winter, to maintain a healthy lifestyle to maintain the immune system. In addition to taking vitamin D, there are other things that can help such as regular exercise, a healthy diet, enough sleep, supplements and stress reduction.

Food for the winter

In winter it is important to support the immune system with the right nutrition. Edible mushrooms, such as Shiitake, are very effective because they support the immune system and at the same time spare the lungs, which is useful in cases of COVID-19, for example. Quercetin is a plant substance that also supports the immune system and is found in capers, onions, apples and leafy vegetables. Turmeric is also a powerful remedy. It has anti-inflammatory effects and is often added to dishes for extra flavor and health benefits. In addition, zinc and selenium are important minerals for the immune system. Zinc stimulates the production of white blood cells and is found in meat, shellfish, seeds and nuts. Selenium also strengthens the immune system and is found in fish, whole grains and Brazil nuts, among others. All in all, it is important to eat a healthy and varied diet, with sufficient vitamins and minerals to keep our immune system strong and healthy.

For more tips, we recommend reading our previous article on the anti-depression diet and our list of foods with a high ORAC value (anti-inflammatory function of food).

Anti-depression diet | ORAC values nutrition

Edible mushrooms

Eating edible mushrooms in winter brings many benefits. It is good to vary with various edible mushrooms as each species contains its own unique substances and supports the immune system in a different way. Below we have highlighted a number of special medicinal mushrooms (pun intended).

Kind Operation
Reishi Anti-inflammatory so better immune system, less depression
Lion’s Mane More Nerve Grow Factor against Alzheimer’s and MS (neurodegeneration)
Turkey tail Better immune system, especially against cancer
Shiitake Activates immune system against viruses via AHCC
Chaga Better immune system
He Shou Wu Protection against DNA aging via Superoxide Dismutase
Psilocybe Hallucinations and BDNF for insights and connections in the brain

Mushroom blog

Support with supplements

In addition to the fact that nutrition is the basis for a good immune system, the supplements below can support the immune system during the winter. Below we list a number that work well during the winter and via the buttons below you can find more information about the relevant supplements and how they work.

  • Vitamin D
  • Multivitamin with vitamins B, C, E and minerals such as zinc and selenium
  • Saffron (Anti-inflammatory and neurotransmitter modulator)
  • Krill or algae oil (because of DHA and EPA)
  • 5-HTP or tryptophan

Vitamin D


Krill oil

Supplements and depression

Does psilocybin work against winter depression?

Psilocybin can work against depression in several ways. Psilocybin has a physical (biochemical) effect on the brain and it provides a subjective experience. Both can contribute to reducing the winter blues or winter depression.


Recent studies have shown that psilocybin has an anti-inflammatory effect in the body. Assuming that depression can be an inflammatory response of the body, the anti-inflammatory effect of psilocybin can help to reduce inflammation levels and thus be effective in treating winter depression.

Psilocybin anti-inflammatory


In addition to the anti-inflammatory effects of psilocybin, psilocybin can promote the growth of new nerve cells in the brain and thus also reduce depressive symptoms. This has to do with the activity of BDNF, a substance released when using psilocybin. BDNF can cause the dendritic processes to grow.



Furthermore, a trip on psilocybin can dispel loneliness by allowing people to experience the unity of the universe. The absence of loneliness has a positive effect on the immune system and thus indirectly on depression. A spiritual journey or insights can also help in dealing with stressors that would otherwise lead to depression.

Subjective experience

Psilocybin structure

Information about psilocybin

As soon as 2024 starts we will have already helped approximately 2000 people with psilocybin sessions. Before the hype surrounding psychedelics started, we wanted to bridge the gap between therapy with psychedelics and a healthy lifestyle. We also want to combine psychedelic therapy with physical health in 2024 and we are happy to help you with this. In order to use our services, we ask you to complete the intake so that we can see whether psilocybin or other psychedelics can be used. If we find contraindications in the intake, we will let you know. If there are no objections, we can schedule a session and provide advice in preparation for your session.

Intake form


Availability of Trip Therapy

Before anyone goes for a psychedelic session it is highly recommended to understand what this means. To learn more about psilocybin, how psilocybin therapy works, what our availability is for private or group sessions, please use the buttons below.


Psilocybin group session


Het originele bericht komt van de onderstaande link

Psilocybin session and depression

Bezoek ook onze partnersites zoals Truffel sessie, lsd therapie, truffel ceremonie, LVL 5 en , psiloflora.


MDMA sessie met analoog
MDMA analoog

MDMA therapie met analoog

MDMA is een stof die veel neurotransmitters vrij laat komen en dat zorgt voor de en stimulerende effecten die het gevoel van verbondenheid en empathie vergroten. De exacte stof MDMA is in Nederland illegaal om in te zetten als therapeutisch hulpmiddel. Zo wordt er sinds vorig jaar al een MDMA analoog w ingezet tijdens wat MDMA sessies.

MDMA-analogen hebben ongeveer dezelfde effecten als MDMA, maar zijn legaal verkrijgbaar omdat ze niet expliciet worden genoemd als illegale substantie in de Opiumwet (Lijst 1 bevat MDMA). Diverse analogen van MDMA werken op dezelfde manier door neurotransmitters zoals de belangrijkere serotonine en dopamine vrij te laten komen. Dit zorgt voor vergelijkbare effecten voor degene die het gebruikt. Sommige analogen bootsten zo goed MDMA na dat mensen geen verschil merken met het origineel. Anderen zoals 3-MMC werken toch net een beetje anders. Van 4-FA is de werking vergelijkbaar met XTC en Speed. Gebruikers geven ook wel aan dat het een variant is tussen deze middelen. Het heeft een stimulerende werking en begint ongeveer na een half uur tot een uur te werken.

Veel verschillende MDMA analogen

Het kiezen tussen verschillende analogen van MDMA kan moeilijk zijn omdat elk van hen verschillende eigenschappen heeft, sommige gevaarlijker dan anderen. Hoewel de meeste analogen effecten hebben die vergelijkbaar zijn met MDMA, kunnen bepaalde eigenschappen zoals toxiciteit, bijwerkingen en effectiviteit voor medicinale doeleinden sterk verschillen. Sommige analogen zijn minder sterk dan MDMA en vereisen hogere doseringen, terwijl andere meer potent zijn. Desalniettemin hebben sommige analogen mogelijk gunstige eigenschappen die kunnen worden gebruikt bij therapieën, zoals hun anxiolytische effecten en daarmee hun vermogen om angst te verminderen. Het is echter niet veilig is om willekeurig verschillende analogen uit te proberen en dat maakt het lastig de juist te vinden.

Wil je niet wachten op de legalisering van MDMA?

Als je niet wilt wachten op de legalisering van MDMA, maar toch een sessie wilt doen die lijkt op MDMA? Neem dan eens een kijkje op deze pagina:

MDMA therapie | MDMA analoog